Dogs are known for being loyal, loving companions; it is no surprise that they fill our lives with joy. However, sometimes dogs can experience depression or anxiety due to a change in environment or other life events. When this occurs, the dog may exhibit decreased appetite, excessive barking, and excessive licking of objects around them.
Trazodone is an FDA-approved drug used successfully in humans for over 50 years to treat insomnia and anxiety disorders.
Recent studies have shown that Trazodone also has an antidepressant effect on dogs, helping them cope with demanding environmental changes, types of anxiety, and stressful events.
This article will discuss the essential information you need to know about using Trazodone for dogs.
Trazodone hydrochloride (Desyrel®) belongs to a class of drugs called serotonin reuptake inhibitors (SSRIs). The FDA first approved it for use in humans in 1981.
Trazodone treats depression and anxiety disorders, chronic insomnia, or other sleep problems. The most common side effects are nausea and dry mouth.
What is Trazodone?
Trazodone hydrochloride (Desyrel®) belongs to a class of drugs called serotonin reuptake inhibitors (SSRIs). The FDA first approved it for use in humans in 1981.
Trazodone treats depression and anxiety disorders, chronic insomnia, or other sleep problems. The most common side effects are nausea and dry mouth.
How does Trazodone work?
Trazodone is an antidepressant medication used to treat depression and anxiety disorders in humans.
It helps regulate the brain’s neurotransmitters related to mood disorders, such as serotonin, dopamine, and norepinephrine. The chemicals promote feelings of happiness and reward.
The drug works by altering the levels of serotonin in the brain. Serotonin is a brain chemical or neurotransmitter responsible for feelings of happiness, joy, and well-being. When there is not enough serotonin in the body, this can cause various symptoms such as depression, anxiety, and irritability.
Trazodone helps increase serotonin levels in the brain, thus improving mood. Taking it can also help dogs stay asleep, reduce anxiety, calm high-energy dogs, and treat them with separation anxiety.
If you are unsure how much to administer, check out the Trazodone dosage chart for dogs.
Trazodone benefits for dogs
Trazodone helps dogs manage symptoms associated with separation anxiety or the need for excessive attention.
Studies published in the Journal of Small Animal Practice and the Journal of Veterinary Behavior Clinical Applications and Research have shown that Trazodone successfully reduces separation anxiety symptoms in dogs.
Studies, such as one published in the Journal of Veterinary Behavior: Clinical Applications and Research, show that Trazodone can help dogs with destructive behaviors such as excessive barking and obsessively licking objects.
It can also help calm dogs that are nervous about specific activities like vet visits.
If you’re struggling with a hyper puppy, talk to your vet. Although your puppy’s energy level is unlikely to be related to any health issues, it’s always best to ask your veterinarian.
If your vet recommends medication to help calm your dog, Trazodone or CBD chews could be healthy options.
Trazodone dosage for dogs
The recommended dose range is between 0.5 mg/kg and 3 mg/kg/day given orally. Give the drug 30 minutes before feeding your dog.
Sometimes, you may increase the dosage to 6 mg/kg/day divided into two daily doses.
Adjust the dose depending on your pet’s response.
Follow dosage recommendations from your veterinarian or certified veterinary technician (CVT).
Consult your veterinarian if symptoms persist long-term because that could indicate a different underlying medical issue.
Trazodone side effects in dogs
Trazodone can cause adverse effects. The most common side effects in dogs are vomiting, diarrhea, and loss of appetite. Other side effects include:
- Difficulty breathing or shortness of breath
- Seizures
- Extreme lethargy
- Loss of coordination
- Lack of interest in food or water
- Hiding or avoiding contact with people and other dogs
- Aggressive behavior
If you notice any of the above side effects in your dog, please consult your veterinarian. They may require an adjustment in dosage or even discontinuation of treatment.
As with any medication, caution is essential when using Trazodone. Never give Trazodone to your dog without the approval of your veterinarian.
Do not give this drug to a dog allergic to trazodone hydrochloride or its inactive ingredients. Also, do not give this drug to a dog under 12 weeks.
Don’t treat pregnant or nursing dogs with this medication.
Xanax vs. Trazodone
Trazodone is a prescription medication you can use to treat anxiety in dogs. The drug is often compared to the drug Xanax.
The medications are similar but not identical. They help reduce anxiety and stress in dogs, but work slightly differently.
Xanax, known as Alprazolam and Niravam, was created to treat human panic disorders. When given to dogs, the drug helps reduce anxiety and stress.
It does this by increasing the amount of serotonin and norepinephrine in the brain. These chemicals are responsible for feelings of relaxation and well-being.
Because of its ability to produce anti-anxiety effects, Xanax is often used to help dogs experiencing separation anxiety, aggression issues, or who need a little extra boost when visiting the veterinarian or groomer.
Pair Trazodone and Diazepam
Using Trazodone and Diazepam together for dogs can offer several benefits, especially for pets experiencing anxiety, stress, or specific behavioral issues.
Here are some key advantages of this combination treatment:
Enhanced anxiety relief: Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) that helps increase serotonin levels in the brain, promoting a calming effect.
Diazepam, a benzodiazepine, works by enhancing the effects of a neurotransmitter called GABA, which further reduces anxiety. Together, they can provide a dual approach to managing anxiety in dogs.
Increased sedation: Combining these medications can have a more pronounced sedative effect for particularly stressed or agitated dogs.
This can be particularly beneficial in situations such as thunderstorms, fireworks, or during travel, where the dog may become highly anxious.
Improved behavior during stress: Trazodone and Diazepam can help create a more manageable state for dogs that exhibit fear-based behaviors.
This can facilitate better socialization and make training more effective, as the dog is less likely to react negatively when feeling calm and secure.
Short-term and long-term use: Trazodone can be used for the long-term management of anxiety, whereas Diazepam is suitable for short-term relief of acute stress.
This allows a veterinarian to customize a treatment plan that effectively addresses the dog’s needs by strategically using both medications.
Minimal risk of over-sedation: When used under veterinary supervision, the dosages of Trazodone and Diazepam can be carefully monitored to prevent excessive sedation.
This consideration helps to maintain the dog’s overall health while effectively managing their anxiety.
Less behavioral disruption: With appropriate dosages, this combination can help mitigate stress-related behaviors, such as barking, destructiveness, and pacing, allowing for a more peaceful environment for the dog and its owners.
Ease vet visits: For dogs anxious about being in a veterinary setting, the combined use of Trazodone and Diazepam can make the experience much more pleasant. Reduced anxiety can help ensure the dog remains calm during exams or treatments.
Before starting any medication regimen, it’s essential to consult with a veterinarian to discuss your dog’s specific needs and ensure the chosen treatment is safe and effective.
Potential risks of using Trazodone
While Trazodone can be beneficial for managing anxiety in dogs, there are potential risks and side effects associated with its use.
Before starting treatment, it’s essential to be aware of these:
Sedation: One of the most common side effects is sedation. While this can be advantageous for anxious dogs, some pets may become overly lethargic, leading to a lack of responsiveness to their surroundings.
Gastrointestinal issues: Trazodone may cause gastrointestinal upset, including vomiting, diarrhea, or changes in appetite.
Behavioral changes: Some dogs may experience changes in behavior, including increased agitation or restlessness, particularly when starting the medication or adjusting dosages.
Allergic reactions: Although rare, some dogs may have allergic reactions to Trazodone, which could manifest as itching, swelling, or difficulty breathing.
Interaction with other medications: Trazodone can interact with other medicines, including certain antidepressants and anti-anxiety drugs. It’s crucial to inform your veterinarian of all medications your dog is taking to avoid potential adverse effects.
Seizures: In rare cases, Trazodone may lower the seizure threshold in susceptible dogs, which could lead to seizures if the dog has a history of seizure disorders.
Withdrawal symptoms: If Trazodone is used for an extended period and suddenly discontinued, withdrawal symptoms may occur. It’s best to taper off the medication under veterinary guidance.
Heart or liver issues: Dogs with preexisting heart or liver conditions may be at greater risk when taking Trazodone. A veterinarian must regularly monitor these cases.
Pregnancy and lactation: The safety of Trazodone in pregnant or nursing dogs hasn’t been fully established, so it’s essential to consult with a veterinarian if your dog falls into these categories.
Always consult your veterinarian before starting Trazodone or changing your dog’s medication regimen. Your vet can provide guidance on potential risks based on your dog’s individual health profile and needs.
Should you use Trazodone?
Our four-legged companions fill our lives with joy, so we would like to reciprocate and make their lives as stress-free as possible.
Unfortunately, our furry friends might become anxious and afraid due to various factors.
In this situation, there are plenty of ways to help reduce increased anxiety. Trazodone is one medication that successfully helps dogs and reduces the risk of behavioral problems for anxious dogs.